Production of Rosuvastatin Calcium Nanoparticles Using Gas Antisolvent Technique
نویسندگان
چکیده
منابع مشابه
Supercritical Antisolvent Technique: Production of Nanoparticles
Supercritical antisolvent micronization (SAS) is a versatile technique that allows the obtainment of different morphologies and dimensions of precipitates, but only in some cases nanoparticles were produced. This work is focused on the selection of the SAS operating conditions to obtain this morphology. A series of experiments on several compounds and different solvents at 40 °C and selected pr...
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The use of supercritical fluids in the area of material processing and for particle formation has been known for several years now. The advantages of supercritical fluid processing include mild operating temperatures, production of solvent free particles and easy micro encapsulation of particles. One of the attractive methods of particle processing using supercritical fluid is the Supercritical...
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شناسایی مخاطرات در واحد 400 پالایشگاه گاز پارسیان. در این پروزه با بکارگیری از تکنیک hazop به شناسا یی مخاطرات ، انحرافات ممکن و در صورت لزوم ارایه راهکارهای مناسب جهت افزایش ایمنی فرا یند پرداخته میگردد. شرایط عملیاتی مخاطره آمیز نظیر فشار و دمای بالا و وجود ترکیبات مختلف سمی و قابل انفجار در واحدهای پالایش گاز، ضرورت توجه به موارد ایمنی در این چنین واحدهایی را مشخص می سازد. مطالعه hazop یک ر...
Dissolution Enhancement of Rosuvastatin Calcium by Liquisolid Compact Technique
In present investigation liquisolid compact technique is investigated as a tool for enhanced dissolution of poorly water-soluble drug Rosuvastatin calcium (RVT). The model drug RVT, a HMG-Co A reductase inhibitor was formulated in form of directly compressed tablets and liquisolid compacts; and studied for in-vitro release characteristics at different dissolution conditions. In this technique, ...
متن کاملRosuvastatin Calcium
Pharmacology: Rosuvastatin selectively and competitively inhibits HMG-CoA reductase, the rate-limiting enzyme in the production of mevalonate, a cholesterol precursor. Rosuvastatin has high activity in, uptake into, and selectivity for the liver, the target organ. It enhances uptake and catabolism of LDL by increasing hepatic LDL receptor levels. It also inhibits the hepatic VLDL synthesis, red...
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ژورنال
عنوان ژورنال: Periodica Polytechnica Chemical Engineering
سال: 2021
ISSN: 1587-3765,0324-5853
DOI: 10.3311/ppch.16629